Acquisition protocol for the studies: Oxford UK Biobank Aligned Controls (OxBAC) and British Israel Research Academic Exchange (BIRAX) study on Microstructural MRI in Healthy Ageing.

The protocol includes sequences matched to the UK Biobank imaging study as well as a specific sequence to study the brain microstructure.

The UK Biobank-matched sequences are the same as those acquired in memory clinic patients of the Oxford Brain Health Clinic on the same scanner (protocol referenced below), to provide a matched healthy control group.

See attached radiographers scanning procedure for full usage guidance. 

Citing this protocol: http://doi.org/tbc

References for scans part of the Oxford Brain Health Clinic protocol:

Clare O'Donoghue, Jasmine Blane, Juliet Semple, Sebastian Rieger, Nicola Aikin, Jon Campbell, Pieter Pretorius, Ludovica Griffanti, Grace Gillis, Thomas W Okell, Mark Chiew, Stephen M Smith, Karla L Miller, & Clare E Mackay. (2022). WIN MR Protocol: Oxford Brain Health Centre (2019_102_BHC). Zenodo. https://doi.org/10.5281/zenodo.6598036

Griffanti L, Gillis G, O'Donoghue MC, Blane J, Pretorius PM, Mitchell R, Aikin N, Lindsay K, Campbell J, Semple J, Alfaro-Almagro F, Smith SM, Miller KL, Martos L, Raymont V, Mackay CE. Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic. Neuroimage Clin. 2022;36:103273. doi: 10.1016/j.nicl.2022.103273. Epub 2022 Nov 21.  https://pubmed.ncbi.nlm.nih.gov/36451375/

References for HARDI, CHARMED, AxCaliber:

Assaf Y, Basser PJ. Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain. Neuroimage. 2005 Aug 1;27(1):48-58.

Assaf Y, Blumenfeld-Katzir T, Y ovel Y, Basser PJ. Axcaliber: A method for measuring axon diameter distribution from diffusion MRI. Magn Reson Med. 2008 Jun;59(6):1347-54.

Acknowledgments: The development of this resource was funded by the Britain-Israel research and Academic Exchange partnership (BIRAX) with Rosetrees and the Israel Ministry of Innovation, Science and Technology. This work was also supported by the NIHR Oxford Health Biomedical Research Centre (NIHR203316) and the Oxford Centre for Integrative Neuroimaging (OxCIN). The Oxford Centre for Integrative Neuroimaging was supported by core funding from the Wellcome Trust (203139/Z/16/Z). JB is supported by the Medical Research Council (MR/N013468/1).

License: This resource is distributed under Creative Commons Attribution 4.0 International Public License (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). 

Susceptibility-weighted MRI (swMRI) scan adapted from the UK Biobank imaging study.

Suitable for SWI and QSM analyses. Coil uncombined images need to be generated at the time of scanning (please refer to the scanning procedure document for details).

T1-weighted structural scan, of 1mm isotropic resolution, matched with the UK Biobank imaging study.

Suitable for structural MRI analyses and base for registration to a standard template (also to aid registration in a functional MRI, diffusion MRI or ASL protocol).

T2-weighted FLAIR scan, matched with the UK Biobank imaging study.

Suitable for structural MRI analyses and lesion segmentation.

Diffusion-weighted scan, multi-shell, matched with the UK Biobank imaging study.

Suitable for fitting diffusion models and run tractography.

Pseudo-continuous Arterial Spin Labelling sequence.

Suitable for perfusion imaging (e.g. to estimate Cerebral Blood Flow and Arterial Transit Time).

Resting-state functional MRI scan, multiband factor 8, matched with the UK Biobank imaging study.

Suitable for resting-state functional connectivity analyses.