Protocol: 2018_018 Baclofen and motor learning
Open Access Status
Open Access (Recommended)Stable URL
https://open.oxcin.ox.ac.uk/protocols/stable/20f44ecf-5b44-45ad-b209-2be705eeb7fc
Original Creation Date
2025-Oct-23 19:11:07
Version
Version 1 Edit 1 @ 2025-Oct-23 19:11:07
Version History
- This is the latest version
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Scanner
MAGNETOM 3T Prisma - Syngo VE11C-SP01
Application
In Vivo
Total Acquisition Time
0h:49m:18s
Coils
- 3T Siemens Head Coil 32ch
Project
2018_018 Baclofen and Motor Learning
Description
This protocol was used in a neuroimaging study where baclofen or placebo was administered to healthy participants in order to investigate the effects of increasing brain inhibition on motor learning and brain neurochemicals. The experimental design is described in more detail in the paper "Baclofen, a GABAB receptor agonist, impairs motor learning in healthy people and changes inhibitory dynamics in motor areas": https://doi.org/10.1162/IMAG.a.979
Keywords
Baclofen Motor Cortex Motor learning MRSIUsage Guidance
Staffing levels: 1 x scanner operator and 1 x researcher
Protocol Structure
- Pilot Jan 2019
Keywords
rs-fMRI
Acquisition Time
0h:6m:10s
Description
Resting state fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence.
Participants were asked to fixate on a white cross presented on a black screen, to blink normally, and to try not to fall asleep.
Keywords
BOLD
Acquisition Time
0h:6m:40s
Description
Task fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence.
Participants were asked to complete the action selection task during this scan. During execute blocks, they had to press a button in response to any shape they saw on the screen. During select blocks, they were asked to press either button one or two, depending on the shape and size of the cue displayed on the screen.
Keywords
BOLD
Acquisition Time
0h:6m:40s
Description
Task fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence.
Participants were asked to complete the serial reaction time task during this scan. Participants were asked to press buttons with their right hand depending on the cues displayed on the screen. There were random blocks, with randomly presented cues, and sequence blocks, where the cues follow a 12-button sequence repeated 5 times in each block. More information on the SRTT is presented in the paper.