Protocol: OxBAC-BIRAX Healthy Ageing (FMRIB 3T)
Open Access Status
Open AccessStable URL
https://open.oxcin.ox.ac.uk/protocols/stable/84018fbb-7f0b-41be-9a3b-973ab9ff29b4
Original Creation Date
2025-May-12 8:37:21
Version
Version 1 Edit 7 @ 2026-Jan-09 15:35:49
Version History
- This is the latest version
- See full history
Scanner
MAGNETOM 3T Prisma - Syngo VE11C-SP01
Application
In Vivo
Total Acquisition Time
0h:58m:40s
Coils
- 3T Siemens Head Coil 32ch
Project
2021_015 BHC-BIRAX
File Attachments
- OxBAC-BIRAX_Healthy_Ageing_FMRIB_3T.docx
- OHBA_3T_BHC_ASL_Appendix.pdf
Description
Acquisition protocol for the studies: Oxford UK Biobank Aligned Controls (OxBAC) and British Israel Research Academic Exchange (BIRAX) study on Microstructural MRI in Healthy Ageing.
The protocol includes sequences matched to the UK Biobank imaging study as well as specific sequences to study the brain microstructure, including structural connectome and cortical layers imaging.
Keywords
Adult Aging Alzheimer's Disease ASL Biobank BOLD Brain Cohort Studies Dementia Diffusion DTI DWI FLAIR fMRI harmonisation Healthy Volunteers Multiband rs-fMRI Structural SWI T1 T2 T2* TOFUsage Guidance
See attached radiographers scanning procedure for full usage guidance.
Citing this protocol: http://doi.org/tbc
“References for scans matched to the UK Biobank imaging study (the same as those acquired in the Oxford Brain Health Clinic, BHC):
Clare O'Donoghue, Jasmine Blane, Juliet Semple, Sebastian Rieger, Nicola Aikin, Jon Campbell, Pieter Pretorius, Ludovica Griffanti, Grace Gillis, Thomas W Okell, Mark Chiew, Stephen M Smith, Karla L Miller, & Clare E Mackay. (2022). WIN MR Protocol: Oxford Brain Health Centre (2019_102_BHC). Zenodo. https://doi.org/10.5281/zenodo.6598036
Griffanti L, Gillis G, O'Donoghue MC, Blane J, Pretorius PM, Mitchell R, Aikin N, Lindsay K, Campbell J, Semple J, Alfaro-Almagro F, Smith SM, Miller KL, Martos L, Raymont V, Mackay CE. Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic. Neuroimage Clin. 2022;36:103273. doi: 10.1016/j.nicl.2022.103273. Epub 2022 Nov 21. https://pubmed.ncbi.nlm.nih.gov/36451375/
References for HARDI, CHARMED, AxCaliber:
Assaf Y, Basser PJ. Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain. Neuroimage. 2005 Aug 1;27(1):48-58.
Assaf Y, Blumenfeld-Katzir T, Y ovel Y, Basser PJ. Axcaliber: A method for measuring axon diameter distribution from diffusion MRI. Magn Reson Med. 2008 Jun;59(6):1347-54.
References for Cortical layers Imaging:
Barazany D, Assaf Y. Visualization of Cortical Lamination Patterns with Magnetic Resonance Imaging. Cereb Cortex. 2012
Acknowledgments: The development of this resource was funded by the Britain-Israel research and Academic Exchange partnership (BIRAX) with Rosetrees and the Israel Ministry of Innovation, Science and Technology. This work was also supported by the NIHR Oxford Health Biomedical Research Centre (NIHR203316) and the Oxford Centre for Integrative Neuroimaging (OxCIN). The Oxford Centre for Integrative Neuroimaging was supported by core funding from the Wellcome Trust (203139/Z/16/Z). JB is supported by the Medical Research Council (MR/N013468/1).
License: This resource is distributed under Creative Commons Attribution 4.0 International Public License (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/).
Protocol Structure
- Protocol v3
- localiser_3plane_32ch
- ep2d_diff_3scan_trace_p2_130
- TE_10_TE_20_TR 30_Magnitude&Phase_t2_swi_tra_p2_.8x.8x1.5mm_PF78
- T1_p2_1mm_fov256_sag_TI_880 (biobank)
- t2_flair_sag_p2_1mm_FS_ellip_pf78
- TOF_3D_neck
- diff_PA_MPopt_MB3_3b0_lowflip
- diff_AP_MPopt_MB3_50b1000_50b2000_8b0_lowflip
- to_ep2d_PCASL
- MB8_FMRI_fov210_2.4mm_resting
- dMRI_MB4_185dirs_d15D45_AP
- dMRI_MB4_6dirs_d15D45_APrev
- IR-EPI_3iso_TI50
- IR-EPI_3iso_TI125
- IR-EPI_3iso_TI175
- IR-EPI_3iso_TI225
- IR-EPI_3iso_TI275
- IR-EPI_3iso_TI325
- IR-EPI_3iso_TI375
- IR-EPI_3iso_TI410
- IR-EPI_3iso_TI440
- IR-EPI_3iso_TI460
- IR-EPI_3iso_TI490
- IR-EPI_3iso_TI510
- IR-EPI_3iso_TI540
- IR-EPI_3iso_TI570
- IR-EPI_3iso_TI600
- IR-EPI_3iso_TI620
- IR-EPI_3iso_TI640
- IR-EPI_3iso_TI660
- IR-EPI_3iso_TI680
- IR-EPI_3iso_TI700
- IR-EPI_3iso_TI720
- IR-EPI_3iso_TI740
- IR-EPI_3iso_TI760
- IR-EPI_3iso_TI780
- IR-EPI_3iso_TI800
- IR-EPI_3iso_TI820
- IR-EPI_3iso_TI840
- IR-EPI_3iso_TI860
- IR-EPI_3iso_TI880
- IR-EPI_3iso_TI910
- IR-EPI_3iso_TI950
- IR-EPI_3iso_TI990
- IR-EPI_3iso_TI1010
- IR-EPI_3iso_TI1050
- IR-EPI_3iso_TI1100
- IR-EPI_3iso_TI1150
- IR-EPI_3iso_TI1200
- IR-EPI_3iso_TI1250
- IR-EPI_3iso_TI1400
- IR-EPI_3iso_TI1550
- IR-EPI_3iso_TI1700
- IR-EPI_3iso_TI2000
- IR-EPI_3iso_TI2100
- IR-EPI_3iso_TI2500
- IR-EPI_3iso_TI3000
Keywords
SWI
Acquisition Time
0h:4m:46s
Description
Susceptibility-weighted MRI (swMRI) scan adapted from the UK Biobank imaging study.
Suitable for SWI and QSM analyses. Coil uncombined images need to be generated at the time of scanning (please refer to the scanning procedure document for details).
Keywords
Biobank Structural T1
Acquisition Time
0h:4m:54s
Description
T1-weighted structural scan, of 1mm isotropic resolution, matched with the UK Biobank imaging study.
Suitable for structural MRI analyses and base for registration to a standard template (also to aid registration in a functional MRI, diffusion MRI or ASL protocol).
Keywords
Biobank Diffusion DTI Multiband
Acquisition Time
0h:0m:36s
Description
B0 scan (non-diffusion-weighted), reversed phase encoding direction with respect to the main diffusion-weighted scan, to correct for susceptibility-induced distortions. Matched with the UK Biobank imaging study.
Keywords
Diffusion DTI
Acquisition Time
0h:0m:44s
Description
HARDI, CHARMED, AxCaliber – B0 scan (non-diffusion-weighted), reversed phase encoding direction with respect to the main diffusion-weighted scan, to correct for susceptibility-induced distortions.