Protocol: 2023_010 US MRI Offline

Open Access Status

Open Access Status

Open Access

Stable URL

https://open.oxcin.ox.ac.uk/protocols/stable/bbd08e71-92b4-494a-96de-e332f8bc9d22

Version Info

Original Creation Date

2025-May-11 22:20:15

Version

Version 1 Edit 1 @ 2025-May-11 22:20:15

Version History

Reference List
Protocol Version Citation Weblink DOI
Version 1 Edit 1 Citing this protocol: Eleanor Martin, Morgan Roberts, Ioana F Grigoras, Olivia Wright, Tulika Nandi, Sebastian W Rieger, Jon Campbell, Tim den Boer, Ben T Cox, Charlotte J Stagg, Bradley E Treeby (2025). Open WIN MR Protocol: TUS-MRI study. Zenodo. https://doi.org/10.5281/zenodo.15360988 Please also cite the first paper published using this protocol: Eleanor Martin, Morgan Roberts, Ioana F Grigoras, Olivia Wright, Tulika Nandi, Sebastian W Rieger, Jon Campbell, Tim den Boer, Ben T Cox, Charlotte J Stagg, Bradley E Treeby (2025). Ultrasound system for precise neuromodulation of human deep brain circuits; DOI https://doi.org/10.1101/2024.06.08.597305 Acknowledgements: This study was supported by the Engineering and Physical Sciences Research Council, UK (EP/P008860/1, EP/P008712/1, EP/S026371/1). The k-Plan simulations were supported by the Ministry of Education, Youth and Sports of the Czech Republic through the e-INFRA CZ (ID:90254). EM was supported by a UKRI Future Leaders Fellowship (MR/T019166/1) and in part by the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) (203145Z/16/Z). CJS was supported by a Wellcome Trust Senior Research Fellowship (224430/Z/21/Z). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z and 203139/A/16/Z). This study was supported by the NIHR Oxford Health Biomedical Research Centre (NIHR203316). The views expressed are those of the authors and not necessarily those of the NHS, NIHR or the Department of Health. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Weblink DOI
Scanning Info

Scanner

MAGNETOM 3T Prisma - Syngo VE11C-SP01

Application

In Vivo

Total Acquisition Time

0h:35m:46s

Coils

  • 3T Siemens Head Coil 32ch
Protocol Info

Project

2023_010 US MR Offline

File Attachments

  1. 2023_010_US_MR_Offline_-_Offline_v1.2.pdf

Description

This protocol was used in a brain stimulation study where transcranial ultrasound stimulation was applied to the lateral geniculate nucleus and brain fMRI data was acquired during stimulation (online sessions) or before and after stimulation (offline sessions). The experimental design is described in more detail in the preprint "Ultrasound system for precise neuromodulation of human deep brain circuits" here: https://www.biorxiv.org/content/10.1101/2024.06.08.597305v1. Specifically, this protocol was used in the offline sessions to acquire fMRI data before and after stimulation.

Keywords

brain stimulation

Usage Guidance

Staffing levels: 1 x scanner operator and 1 x researcher 

Offline v1.2 → Sequence 1: localizer

Keywords

Localiser

Acquisition Time

0h:0m:21s

Description

Localiser

Offline v1.2 → Sequence 2: MB8_FMRI_fov210_2.4mm_resting

Keywords

BOLD

Acquisition Time

0h:10m:0s

Description

Resting state fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence. 

Participants were asked to fixate on a white cross presented on a black screen, to blink normally, and to try not to fall asleep.

Offline v1.2 → Sequence 3: MB4_FMRI_fov210_2.4mm_task_1

Keywords

BOLD

Acquisition Time

0h:8m:12s

Description

Task fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence during visual checkerboard presentation

Offline v1.2 → Sequence 4: fieldmap_2p5mm_FoV_210x210x150

Keywords

Fieldmap

Acquisition Time

0h:1m:40s

Description

Field map image for bias field correction of the fMRI data

Outputs a magnitude and a phase image

Offline v1.2 → Sequence 5: MB4_FMRI_fov210_2.4mm_task_2

Keywords

BOLD

Acquisition Time

0h:8m:12s

Description

Task fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence during visual checkerboard presentation

Offline v1.2 → Sequence 6: t1_mpr_ax_1mm_iso_withNose_32ch_v2

Keywords

T1

Acquisition Time

0h:7m:21s

Description

T1-weighted structural scan used for registration of the fMRI data