Protocol: 2023_008 US MRI Planning

Open Access Status

Open Access Status

Open Access

Stable URL

https://open.oxcin.ox.ac.uk/protocols/stable/bd0dbc3b-ce5d-47a3-ba40-0a7472a1c3f9

Version Info

Original Creation Date

2025-May-11 22:13:06

Version

Version 1 Edit 1 @ 2025-May-11 22:13:06

Version History

Reference List
Protocol Version Citation Weblink DOI
Version 1 Edit 1 Citing this protocol: Eleanor Martin, Morgan Roberts, Ioana F Grigoras, Olivia Wright, Tulika Nandi, Sebastian W Rieger, Jon Campbell, Tim den Boer, Ben T Cox, Charlotte J Stagg, Bradley E Treeby (2025). Open WIN MR Protocol: TUS-MRI study. Zenodo. https://doi.org/10.5281/zenodo.15360988 Please also cite the first paper published using this protocol: Eleanor Martin, Morgan Roberts, Ioana F Grigoras, Olivia Wright, Tulika Nandi, Sebastian W Rieger, Jon Campbell, Tim den Boer, Ben T Cox, Charlotte J Stagg, Bradley E Treeby (2025). Ultrasound system for precise neuromodulation of human deep brain circuits; DOI https://doi.org/10.1101/2024.06.08.597305 Acknowledgements: This study was supported by the Engineering and Physical Sciences Research Council, UK (EP/P008860/1, EP/P008712/1, EP/S026371/1). The k-Plan simulations were supported by the Ministry of Education, Youth and Sports of the Czech Republic through the e-INFRA CZ (ID:90254). EM was supported by a UKRI Future Leaders Fellowship (MR/T019166/1) and in part by the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS) (203145Z/16/Z). CJS was supported by a Wellcome Trust Senior Research Fellowship (224430/Z/21/Z). The Wellcome Centre for Integrative Neuroimaging is supported by core funding from the Wellcome Trust (203139/Z/16/Z and 203139/A/16/Z). This study was supported by the NIHR Oxford Health Biomedical Research Centre (NIHR203316). The views expressed are those of the authors and not necessarily those of the NHS, NIHR or the Department of Health. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. Weblink DOI
Scanning Info

Scanner

MAGNETOM 3T Prisma - Syngo VE11C-SP01

Application

In Vivo

Total Acquisition Time

0h:47m:5s

Coils

  • 3T Siemens Head/Neck Coil 64ch
Protocol Info

Project

2023_008 US MRI Planning

File Attachments

  1. 2023_009_US_MRI_Planning_-_Planning_v1.6.pdf

Description

This protocol was used in a brain stimulation study where transcranial ultrasound stimulation was applied to the lateral geniculate nucleus and brain fMRI data was acquired during stimulation (online sessions) or before and after stimulation (offline sessions). The experimental design is described in more detail in the preprint "Ultrasound system for precise neuromodulation of human deep brain circuits" here: https://www.biorxiv.org/content/10.1101/2024.06.08.597305v1. Specifically, this protocol was used in the first planning session.

Keywords

brain stimulation

Usage Guidance

Staffing levels: 1 x scanner operator and 1 x researcher 

 

Planning v1.6 → Sequence 1: localizer

Keywords

Localiser

Acquisition Time

0h:0m:21s

Description

Localiser

Planning v1.6 → Sequence 2: localizer_2

Keywords

Acquisition Time

0h:0m:21s

Description

Second localiser

Planning v1.6 → Sequence 3: t2_flair_sag_p2_1mm_FS_ellip_pf78

Keywords

T2

Acquisition Time

0h:5m:52s

Description

T2-weighted structural scan used for the ultrasound simulations

Planning v1.6 → Sequence 4: t1_mprage_sag_p2_iso

Keywords

T1

Acquisition Time

0h:5m:58s

Description

Large field-of-view (head and neck) T1-weighted MPRAGE for creation of the head and neck masks

Planning v1.6 → Sequence 5: noT1_petra_tra_FA_1_deg

Keywords

T1

Acquisition Time

0h:3m:44s

Description

Petra scan used as a pseudo-CT for ultrasound simulations

Planning v1.6 → Sequence 6: t1_mpr_ax_1mm_iso_withNose_32ch_v2

Keywords

T1

Acquisition Time

0h:7m:21s

Description

T1-weighted scan used for registration of the fMRI data

Planning v1.6 → Sequence 7: diff_PA_MPopt_MB3_3b0_lowflip

Keywords

Diffusion

Acquisition Time

0h:0m:36s

Description

Diffusion-weighted scan

Planning v1.6 → Sequence 8: diff_AP_MPopt_MB3_50b1000_50b2000_8b0_lowflip

Keywords

Diffusion

Acquisition Time

0h:6m:32s

Description

Diffusion-weighted scan

Planning v1.6 → Sequence 9: MB8_FMRI_fov210_2.4mm_resting

Keywords

BOLD

Acquisition Time

0h:6m:10s

Description

Resting state fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence. 

 

Participants were asked to fixate on a white cross presented on a black screen, to blink normally, and to try not to fall asleep.

Planning v1.6 → Sequence 10: bold_mbep2d_MB3P2_TE25_TR1500

Keywords

BOLD

Acquisition Time

0h:8m:30s

Description

Task fMRI scan acquired with a T2*-weighted 2D multiband EPI sequence during visual checkerboard presentation

Planning v1.6 → Sequence 11: fieldmap_2p5mm_FoV_210x210x150

Keywords

Fieldmap

Acquisition Time

0h:1m:40s

Description

Field map image for bias field correction of the fMRI data

Outputs a magnitude and a phase image