Protocol: 2022_012 FORECAST
Open Access Status
Open AccessStable URL
https://open.oxcin.ox.ac.uk/protocols/stable/eb2dcc91-ac25-4e39-963a-3866b3ed650b
Original Creation Date
2023-Mar-13 19:24:32
Version
Version 1 Edit 5 @ 2023-Mar-28 14:57:51
Version History
- This is the latest version
- See full history
Scanner
MAGNETOM 3T Prisma - Syngo VE11C-SP01
Application
In Vivo
Total Acquisition Time
0h:47m:7s
Coils
- 3T Siemens Spine Tim Coil 32ch
Project
2022_012 FORECAST
File Attachments
- SP2022_012_-_FORECAST_v1.7_ProtDB.pdf
Description
The overarching aims of FORECAST are to identify mechanism-based subgroups in patients with acute/subacute sciatica as well as prognostic factors that predict the transition to pain persistence. This will be achieved using a multimodal approach combining somatosensory and psychosocial profiling, blood inflammatory mediator analyses and advanced neuroimaging including microstructural imaging of lumbar nerve roots. Prognostic variables will be assesed at baseline and outcomes at 3 and 12 months.
The MRI protocol includes:
- Anatomic images with thick slices (2.5 mm) and large FOV used for the reporting.
- Multi-shell DTI scans (2 mm isotropic ; b=0, 700 and 1500 s/mm2).
- High resolution (1 mm isotropic) anatomic scans with optimised T1 and T2 weighted contrasts.
- T2 mapping scan (1.3 mm isotropic).
The total scan time is about 45 minutes.
Please see attached Scan Protocol documents (SP2022_012 FORECAST v1.6 F3T ProtDB.pdf) for full radiographer and equipment requirements.
Keywords
Lumbar nerve roots Pain Sciatica Spinal CordUsage Guidance
Terms of re-use:
We request that future users of this protocol contact the authors to discuss collaboration and authorship agreements related to the reuse.
Contact details:
- PI of the project: Annina Schmid (annina.schmid@ndcn.ox.ac.uk)
- MR physicist: Mohamed Tachrount (mohamed.tachrount@ndcn.ox.ac.uk)
How to cite:
To cite this protocol, please use the following details:
Aikin, Nicola ; Campbell, Jon ; Clare, Stuart ; Koushesh, Soraya ; Parker, David ; Ridgway, Lucy ; Sanders, Michael ; Schmid, Annina ; Semple, Juliet ; Tachrount, Mohamed
WIN MR Protocol: FORECAST
DOI: 10.5281/zenodo.7760905
Protocol Structure
- Protocol v1.6
Keywords
Acquisition Time
0h:0m:26s
Description
This coronal scan has the same FOV size as the diffusion, high resolution structural and the T2 mapping scans. It should be centered at L3/L4 in the midline. It's applied just after the standard localiser to make sure that the wrapping of the arms' signal is not overlapping on the ROI (nerve roots and spinal canal). The position of the arms is adjusted accordingly.
Keywords
Diffusion RESOLVE
Acquisition Time
0h:0m:32s
Description
Coronal diffusion scan based on multi-shot RESOLVE readout. The FOV should cover the lumbar nerve roots. b-value is set to zero and the phase encoding is applied in LR direction to correct for the effects of B0 inhomogeneities (by combining it with the other diffusion scans)
Keywords
Diffusion RESOLVE
Acquisition Time
0h:7m:34s
Description
Coronal diffusion scan based on multi-shot RESOLVE readout. The FOV should cover the lumbar nerve roots. b-value is set to 700 s/mm2 and the phase encoding is applied in RL direction to correct for the effects of B0 inhomogeneities (by combining it with the other diffusion scans)
Keywords
Diffusion RESOLVE
Acquisition Time
0h:7m:56s
Description
Coronal diffusion scan based on multi-shot RESOLVE readout. The FOV should cover the lumbar nerve roots. b-value is set to 1500 s/mm2 and the phase encoding is applied in RL direction to correct for the effects of B0 inhomogeneities (by combining it with the other diffusion scans)